1 | Sept. 10 | 1:00 PM | Jacksonville Jaguars | at | Houston Texans | Houston, TX (NRG Stadium) | CBS | L, 29-7 | |
2 | Sept. 14 | 8:25 PM | Houston Texans | at | Cincinnati Bengals | Cincinnati, OH (Paul Brown Stadium) | NFLN | W, 13-9 | |
3 | Sept. 24 | 1:00 PM | Houston Texans | at | New England Patriots | Foxborough, MA (Gillette Stadium) | CBS | L, 36-33 | |
4 | Oct. 1 | 1:00 PM | Tennessee Titans | at | Houston Texans | Houston, TX (NRG Stadium) | CBS | | |
5 | Oct. 8 | 8:30 PM | Kansas City Chiefs | at | Houston Texans | Houston, TX (NRG Stadium) | NBC | | |
6 | Oct. 15 | 1:00 PM | Cleveland Browns | at | Houston Texans | Houston, TX (NRG Stadium) | CBS | | |
7 | Bye | | | at | | | | | |
8 | Oct. 29 | 4:05 PM | Houston Texans | at | Seattle Seahawks | Seattle, WA (CenturyLink Field) | CBS | | |
9 | Nov. 5 | 1:00 PM | Indianapolis Colts | at | Houston Texans | Houston, TX (NRG Stadium) | CBS | | |
10 | Nov. 12 | 4:05 p.m. | Houston Texans | at | Los Angeles Rams | Los Angeles, CA (Los Angeles Memorial Coliseum) | CBS | | |
11 | Nov. 19 | 1:00 PM | Arizona Cardinals | at | Houston Texans | Houston, TX (NRG Stadium) | FOX | | |
12 | Nov. 27 | 8:30 p.m. | Houston Texans | at | Baltimore Ravens | Baltimore, MD (M&T; Bank Stadium) | ESPN | | |
13 | Dec. 3 | 1:00 PM | Houston Texans | at | Tennessee Titans | Nashville, TN (Nissan Stadium) | CBS | | |
14 | Dec. 10 | 1:00 PM | San Francisco 49ers | at | Houston Texans | Houston, TX (NRG Stadium) | FOX | | |
15 | Dec. 17 | 1:00 PM | Houston Texans | at | Jacksonville Jaguars | Jacksonville, FL (EverBank Field) | CBS | | |
16 | Dec. 25 | 4:30 PM | Pittsburgh Steelers | at | Houston Texans | Houston, TX (NRG Stadium) | NBC/NFLN/Amazon | | |
17 | Dec. 31 | 1:00 PM | Houston Texans | at | Indianapolis Colts | Indianapolis, IN (Lucas Oil Stadium) | CBS | | |